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Last updated: Lupus Nephritis…
on 26 Aug 2016

Alfacalcidol (1╬▒hydroxycholecalciferol)

  • Inhibition of parathyroid hormone release
  • Suppression of PTH production
  • Increase in serum calcium levels

  • Alfacalcidol is an activated form of cholecalciferol (Vitamin D). Capsules: 0.25 micrograms, 0.5 micrograms, 1 microgram
  • Oral drops: 2 micrograms/ml (1 drop contains approximately 0.1 microgram). Injection: 2 micrograms/ml

  • Hypercalcaemia, metatastic calcification

  • Monitor calcium closely. Symptoms of hypercalcaemia include: metallic taste, headache, nausea, weakness, polyuria, polydipsia, constipation, dry mouth, muscle and bone pain
  • Watch for arrhythmias if used with digoxin

Note: red eyes may indicate hypercalcaemia


  • Pruritus, rash

  • 0.25-1 micrograms daily adjusted to serum calcium level
  • Higher doses may be required post parathyroidectomy to maintain calcium levels in the normal range

  • Dose as in normal renal function
  • May be given three times a week to minimise effect on serum calcium; and for patients on thrice weekly haemodialysis to aid adherence

  • Larger doses may required if given in combination with carbamazepine, phenytoin or primidone

ALFACALCIDOL#0.25 micrograms#see prescribing section#PO#8

  • Alfacalcidol is a form of vitamin D
  • If you develop a rash, try moisturisers to soothe the rash. If severe, see your doctor
  • If you experience loss of appetite, weakness or red eyes, see your doctor
  • Alfacacidol capsules contain gelatine. Oral drops must be stored in the fridge