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Last updated: Lesson of the Month - October 2017…
on 17 Oct 2017

Iron (IV)

  • Treatment or prophylaxis of iron deficiency anaemia

  • Venofer® iron sucrose; 100 mg/5ml
  • Cosmofer® iron dextran; 100 mg/2ml, 500 mg/10ml
  • Ferrinject® ferric carboxymaltose; 100 mg/2ml, 500 mg/10ml
  • Monofer® iron(III) isomaltoside 1000; 100 mg/ml
  • Rienso® ferumoxytol 30 mg/ml
  • Prescribe by brand

  • Iron overload, anaemia not caused by iron deficiency
  • Hypersensitivity to iron or to any of the excipients
  • Pregnancy first trimester

  • Monitor iron stores. Aim for a ferritin 100-500 ng/ml and TSAT >20%
  • Anaphylactic reactions can occur with all preparations. A test dose is recommended before the first dose; and before each dose with Iron Dextran. Care in asthmatic patients
  • Parenteral iron must be used with caution in cases of acute or chronic infection. It is recommended that the administration of IV iron is stopped in patients with on-going bacteraemia

  • Metallic taste, hypotension, fever and shivering, allergic reactions

  • A test dose is required before the first dose
  • Patients on HD: varies from 20 mg each dialysis to 100 mg weekly, fortnightly or monthly
  • Patients not on HD: varies between centres. Examples include 100 mg fortnightly for 3 doses or 1g as a total dose infusion

  • As in normal renal function, not dialysed

  • Reduced absorption of oral iron, dimercaprol – avoid concomitant use

VENOFER#100 mg#see prescribing section#IV#

  • Preparation used and dose given varies according to local protocols