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Last updated: Lupus Nephritis…
on 26 Aug 2016

Alfacalcidol (1αhydroxycholecalciferol)



Indication
  • Inhibition of parathyroid hormone release
  • Suppression of PTH production
  • Increase in serum calcium levels
Preparations
  • Alfacalcidol is an activated form of cholecalciferol (Vitamin D). Capsules: 0.25 micrograms, 0.5 micrograms, 1 microgram
  • Oral drops: 2 micrograms/ml (1 drop contains approximately 0.1 microgram). Injection: 2 micrograms/ml
Contraindications
  • Hypercalcaemia, metatastic calcification
Cautions
  • Monitor calcium closely. Symptoms of hypercalcaemia include: metallic taste, headache, nausea, weakness, polyuria, polydipsia, constipation, dry mouth, muscle and bone pain
  • Watch for arrhythmias if used with digoxin

Note: red eyes may indicate hypercalcaemia

Side-effects
  • Pruritus, rash
Dose
  • 0.25-1 micrograms daily adjusted to serum calcium level
  • Higher doses may be required post parathyroidectomy to maintain calcium levels in the normal range
Dose in renal impairment
  • Dose as in normal renal function
  • May be given three times a week to minimise effect on serum calcium; and for patients on thrice weekly haemodialysis to aid adherence
Interactions
  • Larger doses may required if given in combination with carbamazepine, phenytoin or primidone
How to Prescribe View Details
Patient comment
  • Alfacalcidol is a form of vitamin D
  • If you develop a rash, try moisturisers to soothe the rash. If severe, see your doctor
  • If you experience loss of appetite, weakness or red eyes, see your doctor
  • Alfacacidol capsules contain gelatine. Oral drops must be stored in the fridge

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